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KMID : 0378619960130010126
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Baptist Hospital Medical Journal
1996 Volume.13 No. 1 p.126 ~ p.133
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A Comparison of the Analgesic and Side Effects of Continuous Epidural Morphine and Nalbuphine for Postoperaive Pain
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Abstract
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Background:
@EN A number of recent reports have described the usefulness of the epidural injection of narcotics for the relief of postoperative pain. Morphine, a u-receptor agonist, produce strong analgesic effect with some side effects. Nalbuphine, is a
u-antagonist and k-agonist, has an analgesic effect comparable to morphine with little side effects.
@ES Methed:
@EN We divided 60 patients into 3 groups utilizing the five-day Baxter Infusor in 0.125% bupivacaine at 0.5ml/hr: 1) Group M (n=20) received initial 2mg of bolus +2mg/day of maintenance morphine 2) Group N(n-20): initial 4mg of bolus+ maintenance
8mg/day nalbuphine 3) Group M+N(n=20); initial 2mg morphine of bolus+ maintenance 8mg/day nalbuphine Analgesic effect was evaluated by visual analogue scale(0~10) at 6, 12, 18, 24 and 48 hour postoperatively. Changes in blood pressure, heart
rate,
and
incidence of side effects were observed.
@ES Results: No significant hemodynamic changes were seen in any of the groups. The patients of group M and M+N get less pain than group N but side-effects of group M were significantly more than group N, M+N.
@ES Conclusion:
@EN Nalbuphine hydrochloride could be better agent than morphine in terms of complication and the dose of group M+N(initial morphine 2mg of bolus+maintenance 8mg/day nalbuphine) may be recommended for postoperative analgesia.
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KEYWORD
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